Loss-of-function mutations in ndh do not confer delamanid, ethionamide, isoniazid, or pretomanid resistance in Mycobacterium tuberculosis

Sushil Pandey, Catherine Vilcheze, Jim Werngren, Arnold Bainomugisa, Mikael Mansjo, Ramona Groenheit, Paolo Miotto, Daniela M. Cirillo, Christopher Coulter, Alain R. Baulard, Thomas Schon, William R. Jacobs Jr, Kamel Djaout, Claudio U. Koser

Antimicrobial agents and chemotherapy（2024）

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Abstract

Results from clinical strains and knockouts of the H37Rv and CDC1551 laboratory strains demonstrated that ndh (Rv1854c) is not a resistance-conferring gene for isoniazid, ethionamide, delamanid, or pretomanid in Mycobacterium tuberculosis. This difference in the susceptibility to NAD-adduct-forming drugs compared with other mycobacteria may be driven by differences in the absolute intrabacterial NADH concentration.

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Key words

Mycobacterium tuberculosis,delamanid,ethionamide,isoniazid,pretomanid

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