Direct Regioselective Reductive Allylation of Imines: Application to Synthesis of Oxazines with Halogenated Reagent
ORGANIC LETTERS(2023)
摘要
Oxazines are an important class of compounds in oxazine ligands and medical chemistry. Here, we describe a linear-selective allylation of imines with allyl electrophiles via cross-electrophile coupling reactions, followed by cyclization with halogenated reagents, providing a new strategy to afford oxazine compounds with a tetrasubstituted carbon center. Mechanistic studies indicate that alpha-amino carbanion, generated by successive single-electron transfer processes, is a key intermediate for nucleophile attack on pi-allylpalladium in photoredox/palladium catalysis.
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