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Glycodiversification of Gentamicins Through in Vivo Glycosyltransferase Swapping Enabled the Creation of Novel Hybrid Aminoglycoside Antibiotics with Potent Activity and Low Ototoxicity

Xinyun Jian,Cheng Wang, Shijuan Wu,Guo Sun,Chuan Huang, Chengbing Qiu, Yuanzheng Liu,Peter F. Leadlay, Dong Liu,Zixin Deng,Fuling Zhou,Yuhui Sun

ACTA PHARMACEUTICA SINICA B（2024）

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关键词
Aminoglycoside,Biosynthetic engineering,Ototoxicity
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