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Individual Collagen Fibrils Investigated using Polarization-Resolved Second Harmonic Generation Microscopy

Macaulay Harvey,Richard Cisek,Laurent Kreplak,Danielle Tokarz

2023 Photonics North (PN)（2023）

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Abstract
We investigate individual collagen fibrils using polarization SHG microscopy. It is found that polarization SHG is sensitive to changes in fibril structure caused by hydration, and changes in fibril out of plane orientation as a result of buckling.
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Key words
Nonlinear optics,Microscopy,Second Harmonic Generation,Collagen,Biophotonics
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