Molekularer Abdruck oder Selektion bei der Erzeugung biomimetischer Specifyer

Aptamers and imprinted polymers (MIPs) for the recognition of low-molecular substances, proteins, nucleic acids, viruses and cells have been developed with the advantage over antibodies of not having to use animals for their production. They can also be generated against toxic substances and structures of low immunogenicity. Their affinities to the target molecules, especially for protein biomarkers, are mostly comparable to those of antibodies. However, the cross-reactivity of highly abundant interferences is still a challenge for MIPs.