The second messenger c-di-AMP controls natural competence via ComFB signaling protein
biorxiv(2023)
摘要
Natural competence requires a contractile pilus system. Here, we provide evidence that the pilus biogenesis and natural competence in cyanobacteria are regulated by the second messenger c-di-AMP. Furthermore, we show that the ComFB signaling protein is a novel c-di-AMP-receptor protein, widespread in bacterial phyla, and required for DNA uptake.
### Competing Interest Statement
The authors have declared no competing interest.
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