基于m6A甲基化探讨痰瘀同治动脉粥样硬化的科学内涵
China Journal of Chinese Medicine（2023）
Abstract
"痰瘀互结"是动脉粥样硬化(atherosclerosis,AS)的主要病机.m6A是RNA中最为常见的修饰,其动态平衡的改变会影响AS生理功能.METTL14 是一种重要的m6A甲基化酶,在RNA的m6A甲基化过程中起着核心作用.METTL14 高表达与中医"痰、瘀"相对应,活血化痰与抑制METTL14 高表达在AS的治疗中异曲同工.活血化痰中药对预防和改善动脉粥样硬化有显著效果.
MoreKey words
atherosclerosis,methylation of m6 A,treating from perspective of Phlegm and blood stasis,METTL14,drugs for promoting blood circulation and resolving Phlegm
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