Dynamic Susceptibility Contrast Perfusion, Part 2: Deployment With and Without Contrast Leakage Present.

A thorough description of perfusion analysis and basic DSC MR acquisition concepts has been described in the companion article to this article, which the interested reader may also find useful. DSC MR imaging requires an MR imaging pulse sequence that is sensitive to magnetic susceptibility changes to register the contrast concentration changes when GBCA passes through the capillary bed. Any pulse sequence that has T2∗-weighting can be used to pick up these changes, provided that the sequence is fast enough to acquire an image of that slice of tissue at least every 1 to 2 second.