The environmental pollutant BDE-47 modulates immune responses in in vitro and in vivo murine models

Bianca Barletta,Silvia Corinti,Francesca Maranghi,Sabrina Tait,Roberta Tassinari,Andrea Martinelli,Alessandra Longo,Valeria Longo,Paolo Colombo,Gabriella Di Felice,Cinzia Butteroni

Chemosphere（2024）

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摘要

2,2′,4,4′-tetra-bromodiphenyl ether (BDE-47) is widespread in the environment and biological samples. Its association with health risks is an increasing concern, yet information on BDE-47 immunotoxicity remains limited. This study investigated the impact of BDE-47 on innate and adaptive immune responses through in vitro and in vivo approaches.

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关键词

2,2′,4,4′-tetrabromodiphenyl ether (BDE-47),RAW 264.7 mouse macrophage cell line,Balb/c mice,Immunotoxicity,T-dependent antibody response (TDAR),Keyhole limpet hemocyanin (KLH)

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