Nanocomposite Materials Based on Polylactide and Gold Complex Compounds for Absorbed Dose Diagnostics in BNCT
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES(2023)
Abstract
In this study, approaches to the synthesis of complex compound of gold with cysteine [AuCys]n for measuring absorbed dose in boron neutron capture therapy (BNCT) were developed. The dependence of the complex particle size on pH were established. Nanocomposite materials based on polylactide containing [AuCys]n particles with an average size of about 20 nm were obtained using the crazing mechanism. The structure of obtained materials was studied by electron microscopy. The release kinetics of [AuCys]n from polymer matrix were investigated. Release of [AuCys]n from the volume of the polymeric matrix had a delayed start-this process began only after 24 h and was characterized by an effective rate constant of 1 mu g/h from a 20 mg composite sample. At the same time, in vitro studies showed that the concentration of 6.25 mu g/mL was reliably safe and did not reduce the survival of U251 and SW-620 cells.
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Key words
nanocomposite,polylactide,cancer therapy,gold complex,drug delivery,release,biocompatibility,hydrolysis
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