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Lack of Methylation Changes in GJB2 and RB1 Non-coding Regions of Cochlear Implant Patients with Sensorineural Hearing Loss.

Angelo Augusto M Sumalde,Ivana V Yang,Talitha Karisse L Yarza,Celina Ann M Tobias-Grasso,Ma Leah C Tantoco,Elizabeth Davidson,Abner L Chan,Mahshid S Azamian,Teresa Luisa G Cruz,Seema R Lalani,Maria Rina T Reyes-Quintos,Eva Maria Cutiongco-de la Paz,Regie Lyn P Santos-Cortez,Charlotte M Chiong

Acta medica Philippina（2023）

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Abstract
Our study showed no changes in methylation at the selected CpG regions in and in the two comparison groups with or without SNHL. This may be due to a lack of environmental exposures to these target regions. Other epigenetic marks may be present around these regions as well as those of other HL-associated genes.
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Key words
cochlear implant patients,hearing loss,methylation changes,gjb2,non-coding
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