Multiscale cortical morphometry reveals pronounced regional and scale-dependent variations across the lifespan
arxiv(2023)
摘要
Motivation: Characterising the changes in cortical morphology across the
lifespan is fundamental for a range of research and clinical applications. Most
studies to date have found a monotonic decrease in commonly used morphometrics,
such as cortical thickness and volume, across the entire brain with increasing
age. Any regional variations reported are subtle changes in the rate of
decrease. However, these descriptions of morphological changes have been
limited to a single length scale. Here, we delineate the morphological changes
associated with the healthy lifespan in multi-scale morphometrics.
Methods: Using MRI from subjects aged 6-88 years from NKI (n=833) and CamCAN
(n=641), we computed several morphometrics at spatial scales ranging from 0.32
mm to 3 mm.
Results: On the level of whole cortical hemispheres, lifespan trajectories
show diverging and even opposing trends at different spatial scales, in
contrast to the monotonic decreases of volume and thickness described so far.
Pronounced regional differences between lobes also became apparent in scales
over 0.7 mm.
Conclusion: Our study provides a comprehensive multi-scale description of
lifespan effects on cortical morphology in an age range from 6-88 years. In
future, this can be used as a normative model to compare individuals or
cohorts, hence identifying morphological abnormalities. Our results reveal the
complementary information contained in different spatial scales, suggesting
that morphometrics should not be considered as mere scalars, but as functions
of length scale.
更多查看译文
AI 理解论文
溯源树
样例
生成溯源树,研究论文发展脉络
Chat Paper
正在生成论文摘要