Examining American attitudes toward vaccination during the COVID-19 pandemic from the perspective of negative and positive rights.

We examine the likely acceptance of the COVID-19 vaccine in the period prior to political polarization around vaccine mandates. Two representative cross-sectional surveys of 1,000 respondents were fielded in August and December 2020. The surveys included items about the COVID-19 vaccine and vaccine mandates. Respondents self-identifying as liberal were the least likely to believe the vaccine had undisclosed harmful effects (p< .001), conservatives were the most likely (p < .001), and moderates fell in between. Individuals with a bachelor's degree were less likely to think the vaccine had undisclosed harmful effects than individuals without a bachelor's degree (p < .001), and 60.5% of those individuals did not support a government vaccine mandate. Political ideology was more often strongly associated with avoiding government involvement compared to education level. In summary, both liberal political ideology and higher education were significantly associated with endorsing intended vaccine uptake. We discuss these results in terms of positive versus negative rights.