Rpd3S meets the nucleosome

Two recent reports in Cell Research present cryo-electron microscopy structures of the Rpd3S HDAC complex bound to the nucleosome.These structures provide novel insight into the binding properties of the Rpd3S subunits Sin3,Rco1 and Eaf3 to DNA and Rco1 and Eaf3 to unmodified H3K4 and methylated H3K36,respectively,and also provide a fascinat-ing look at the unique properties of Rpd3 in recognizing specific acetylated lysines for deacetylation in the context of Rpd3S.