Mechanism of analgesic effect of fire needle on peripheral sensitization in rats with neuropathic pain induced by chemotherapy.

OBJECTIVES:This study aims to explore the analgesic mechanism of fire needle on peripheral sensitization in rats with neuropathic pain(NP) induced by oxaliplatin, so as to investigate its mechanism in improving peri-pheral sensitization. METHODS:Male SD rats aged 8 weeks were randomly divided into 4 groups：normal group( nnnnRESULTS:Compared with the normal group, the model group had decreased paw withdrawal threshold(PWT) after modeling( PPPPPPPCONCLUSIONS:Fire needle can improve mechanical pain threshold and reduce the contents of peripheral inflammatory factors in rats with oxaliplatin-induced NP. This effect may be related to the inhibition of mast cell activation and the inhibition of TPS, TRPV1 and PAR2 protein expressions, in the local areas of acupoints.