Amino acids fuel fibroblast-like synoviocyte activation and arthritis by regulating chemokine expression and leukocyte migration.

Thomas Karonitsch,Victoria Saferding,Markus Kieler,Karolina von Dalwigk,Anela Tosevska,Gerwin Heller,Mirjam Dellinger,Birgit Niederreiter,Felix Kartnig,Carl W Steiner,Philippe Georgel,Hans P Kiener,Josef S Smolen,Adelheid Korb-Pap,Michael Bonelli,Daniel Aletaha,Stephan Blüml

Arthritis & rheumatology (Hoboken, N.J.)（2023）

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摘要

AA-deprivation reduces the severity of arthritis by suppressing the expression of IRF1-STAT1-driven chemokines, which are crucial for leukocyte recruitment to the arthritic joint. Overall, our study provides novel insights into critical determinants of inflammatory arthritis and may pave the way for dietary intervention trials in RA. This article is protected by copyright. All rights reserved.

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