A Historic Cohort Analysis of Radiographic and Serologic Findings in Patients With Scleroderma and Interstitial Lung Disease

Background/ObjectiveFew studies have investigated associations between rheumatologic serology patterns and different interstitial lung disease (ILD) patterns.MethodsWe present novel findings of a historic cohort study (n = 454) with data collected from 2011 to 2021 within our hospital system. In this institutional review board-approved study, data regarding rheumatologic serologies and ILD patterns were noted based on chart review in patients with scleroderma. The Kruskal-Wallis rank sum and chi 2 tests were used for statistical analysis.ResultsResults showed a statistically significant association between anti-U1 snRNP with lymphoid interstitial pneumonia, which has not been previously described.ConclusionsWe demonstrated novel serologic associations with ILD patterns, which have important clinical implications. More robust and high-powered studies are needed to elucidate the role of serologic testing and their association with ILD phenotypes.