Antibacterial Lanostane Triterpenoids from the Fruiting Bodies of Ganoderma tsugae

Chemistry of Natural Compounds(2023)

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摘要
phytochemical investigation on the ethanol extract from the fruiting bodies of Ganoderma tsugae resulted in the isolation of two undescribed lanostane triterpenoids, lanosta-8,24 E -dien-3,7,11-trioxo-26,27-dihydroxy ( 1 ) and 22,23,24,25,26,27-hexanorlanosta-7,9(11)-dien-3 β -acetyloxy-15-hydroxy-20-oxo ( 2 ). Their structures were determined by spectral methods such as 1D and 2D ( 1 H– 1 H COSY, HMQC, NOESY, and HMBC) NMR spectroscopy, in addition to high-resolution mass spectrometry. The in vitro pharmacological studies revealed 2 possessed antibacterial activity against 5 anaerobic bacteria with MIC values less than 30 μg/mL .
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关键词
Ganoderma tsugae,Ganodermataceae,lanostane triterpenoids,antibacterial activity
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