Аnticoagulation Effects of Leucine-Containing Glyprolines in Hypercoagulation

The effects of two leucine-containing glyproline peptides Leu-Pro-Gly-Pro and Pro-Gly-Pro-Leu, including leucine from the N- and C-ends of the molecules, on the parameters of platelet (primary) and plasma hemostasis were studied. Peptides were administered intranasally for five days at a daily dose of 500 μg/kg of body weight under conditions of hypercoagulation caused by intravenous administration of tissue thromboplastin into rats with metabolic syndrome on a high-calorie diet. Both peptides contributed to an increase in all types of fibrinolysis (total, enzymatic, and non-enzymatic), anticoagulant activity, and a decrease in platelet aggregation in rat blood plasma compared with the control. The maximum anticoagulant effect was established in a peptide containing leucine from the C-terminus.