Pathophysiology, Diagnosis, Treatment and Emerging Neurotherapeutic Targets for Progressive Multiple Sclerosis The Age of PIRA

Progressive forms of MS affect more than one million individuals worldwide. Improved understanding of mechanisms underlying MS progression, identification and validation of biomarkers, identification of novel therapeutic targets, and improved trial design are needed to further propel progress in the management of individuals with progressive forms of MS. Effective therapies targeting progressive mechanisms in MS remains a significant unmet need, though there are several encouraging potential therapeutics on the horizon. The future of progressive MS is indeed bright.