ACMSD mediated de novo NAD+ biosynthetic impairment in cardiac endothelial cells as a potential therapeutic target for diabetic cardiomyopathy

Fangfang Zeng, Peng Zhou,Meng Wang, Lijie Xie,Xinmei Huang,Yilin Wang,Jinya Huang,Xiaoqing Shao,Yeping Yang,Wenjuan Liu,Maocheng Gu,Yifei Yu,Fei Sun,Min He,Yiming Li,Zhaoyun Zhang,Wei Gong,Yi Wang

Diabetes research and clinical practice（2023）

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摘要

•Increased expression of ACMSD in cardiac endothelial cells leads to impaired de novo synthesis of NAD+ in diabetic heart.•Increased ACMSD enzyme activity in diabetic patients, which was a risk factor of left ventricular diastolic dysfunction.•Inhibition of ACMSD to boost NAD+ level could be therapeutic target to ameliorate diabetic cardiomyopathy.

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关键词

ACMSD,Diabetic cardiomyopathy,Endothelial cells,NAM,NAD+

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