Come for the atmosphere, stay for the interactions: Deciphering small molecule partitioning into biomolecular condensates
Cell chemical biology(2023)
摘要
Optimizing pharmacokinetic properties remains challenging but is generally guided by a set of structural rules. However, no such rule set exists for intracellular distribution. Kilgore et al.1 have examined small molecule partitioning within biomolecular condensates, yielding findings that could open a new window in the drug design and discovery process.
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