Characterization of reverse-engineered anti-PF4 stereotypic antibodies derived from serum of patients with VITT

Jing Jing Wang,Marijn van der Neut Kolfschoten, Lucy Rutten,Bridie Armour, Chee Wee Tan,Tim Chataway, Rinke Bos, Annemart Koornneef, Pravien Abeywickrema,Rick Kapur, Leendert Porcelijn, Midia Khalifa, Ava Sadi,Pascale Bouchier, Eleni Kourkouta,Aditya Perkasa, Ted Kwaks,Roland Zahn, Laura Solforosi,Tom P. Gordon

BLOOD（2024）

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摘要

This study presents a novel reverse-engineering approach to generate recombinant anti-PF4 antibodies from VITT-patient sera. These antibodies recapitulate functional effects of original serum anti-PF4 clonotypes, identify key PF4 binding residues and hold promise as valuable tools to investigate VITT etiology.

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