Independent Prediction of Child Psychiatric Symptoms by Maternal Mental Health and Child Polygenic Risk Scores

Lawrence M. Chen,Irina Pokhvisneva,Marius Lahti-Pulkkinen,Tuomas Kvist,Jessie R. Baldwin,Carine Parent,Patricia P. Silveira,Jari Lahti,Katri Räikkönen,Vivette Glover,Thomas G. O’Connor,Michael J. Meaney,Kieran J. O’Donnell

Journal of the American Academy of Child & Adolescent Psychiatry（2023）

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摘要

These findings highlight the genomic contribution to the fetal origins of mental health hypothesis and further evidence that prenatal maternal depression and anxiety are robust in utero risks for child/adolescent psychiatric symptoms.

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关键词

ALSPAC,child development,fetal origins of mental health,maternal depression,polygenic risk score

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