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Repurposing AZD5438 and Dabrafenib for Cisplatin-Induced Acute Kidney Injury.

Chithra K Pushpan,Daniel F Kresock,Matthew A Ingersoll,Richard D Lutze,Darby L Keirns,William J Hunter,Khalid Bashir,Tal Teitz

Journal of the American Society of Nephrology : JASN（2023）

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Abstract
Cisplatin-induced damage to the inner ear and kidneys share similar cellular beneficial responses to AZD5438 and dabrafenib highlighting the potential therapeutic use of these agents to treat both cisplatin-mediated kidney damage and hearing loss.
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