Tumor- and Nerve-Derived Axon Guidance Molecule Promotes Pancreatic Ductal Adenocarcinoma Progression and Metastasis through Macrophage Reprogramming.

Noelle R J Thielman, Vanessa Funes,Sanjana Davuluri,Hector E Ibanez,Wei-Chih Sun,Juan Fu,Keyu Li, Stephen Muth,Xingyi Pan,Kenji Fujiwara,Dwayne Thomas, MacKenzie Henderson,Selina Shiqing Teh,Qingfeng Zhu,Elizabeth Thompson,Elizabeth M Jaffee,Alex Kolodkin,Fengxi Meng,Lei Zheng

bioRxiv : the preprint server for biology（2023）

引用 0|浏览10

暂无评分

摘要

This study established the dual role of axon guidance molecule, SEMA3D, in the malignant transformation of pancreatic epithelial cells and of nerve-derived SEMA3D in PDA progression and metastasis. It revealed macrophage reprogramming as the mechanism underlying bothroles. Together, this research elucidated how inflammatory responses promote invasive PDA progression and metastasis through an oncogenic process.

查看译文

AI 理解论文

溯源树

样例

生成溯源树，研究论文发展脉络

Chat Paper

正在生成论文摘要