Plant pathogenic fungi hijack phosphate starvation signaling with conserved enzymatic effectors
biorxiv(2023)
摘要
Phosphate availability modulates plant immune function and regulates interactions with beneficial, phosphate-providing, microbes. Here, we describe the hijacking of plant phosphate sensing by a family of Nudix hydrolase effectors from pathogenic Magnaporthe oryzae and Colletotrichum fungi. Structural and enzymatic analyses of the Nudix effector family demonstrate that they selectively hydrolyze inositol pyrophosphates, a molecule used by plants to monitor phosphate status and regulate starvation responses. In M. oryzae , gene deletion and complementation experiments reveal that the enzymatic activity of a Nudix effector significantly contributes to pathogen virulence. Further, we show that this conserved effector family induces phosphate starvation signaling in plants. Our study elucidates a molecular mechanism, utilized by multiple phytopathogenic fungi, that manipulates the highly conserved plant phosphate sensing pathway to exacerbate disease.
One-Sentence Summary A family of conserved enzyme effectors from pathogenic fungi manipulate plant phosphate sensing to promote infection.
### Competing Interest Statement
The authors have declared no competing interest.
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