细菌程序性细胞死亡及其在抗菌治疗中的应用前景

Liu Wei-jia, Fang Fang, Zhu Liang,Xue Yun-xin,Wang Dai

Chinese Journal of Antibiotics(2023)

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Abstract
细菌程序性细胞死亡(programmed cell death,PCD)是细菌在压力环境下自发牺牲部分亚群以提高细菌群体生存而产生的编程性死亡,该利他现象受到越来越多的关注.耐药菌的出现为病原菌杀伤带来挑战,鉴于细菌PCD在耐药菌产生与治疗方面的重要作用,本文从PCD角度详细分析细菌应对抗生素压力的方式,阐明PCD为抗菌治疗提供的新策略,为合理使用这把"双刃剑"提供理论支持.
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Key words
Bacteria,Programmed cell death,Antibiotic resistance,Antimicrobial therapy,Altruism
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