呋喃妥因作用机制与临床应用研究进展及联合用药策略
Chinese Journal of Antibiotics（2023）
Abstract
细菌耐药性的持续攀升及新型抗菌药物研发进展缓慢,使得临床抗感染治疗面临巨大挑战.早期抗生素呋喃妥因具有较强的抗菌活性和较低的临床耐药率,被重新考虑作为治疗尿路感染的一线药物,但其确切的分子作用靶点仍不清楚.本文回顾了呋喃妥因的抗菌和耐药机制、临床应用现状及联合用药研究,以期为呋喃妥因的合理使用及抗菌策略制定提供参考.
MoreKey words
Nitrofurantoin,Antimicrobial mechanism,Clinical application,Drug resistance mechanism,Combination drug therapy
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