Ultrasound-assisted green synthesis and in silico study of 6-(4-(butylamino)-6-(diethylamino)-1,3,5-triazin-2-yl)oxypyridazine derivatives
Green Processing and Synthesis(2023)
摘要
Eco-friendly ultrasound-assisted synthesis of a series of 3-N-substituted 6-((4-(butylamino)-6-(diethylamino)-1,3,5-triazin-2-yl)oxy)pyridazin-3(2H)-one derivatives and in silico study to predict their biological activities were carried out. Physicochemical and pharmacokinetic properties were obtained. Absorption, distribution, metabolism, excretion and toxicity properties and bioavailability index were calculated. A comparative analysis of structural similarity based on the Tanimoto coefficient was carried out.
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关键词
ultrasound-assisted synthesis,green chemistry,6-(1,3,5-triazin-2-yl)oxypyridazine,in silico study
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