Pharmacokinetics, Safety, and Tolerability of Once-Daily Darunavir With Cobicistat and Weekly Isoniazid/Rifapentine.

Kristina M Brooks,Alice K Pau, Doris Swaim, Haden T Bunn,Lilian Adeojo,Charles A Peloquin,Parag Kumar,Joseph A Kovacs,Jomy M George

Journal of acquired immune deficiency syndromes (1999)（2023）

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摘要

Darunavir exposures were significantly decreased with HP coadministration. Temporal relationships between HP coadministration and the extent of induction or mixed inhibition/induction of darunavir metabolism were apparent. Coadministration of darunavir/cobicistat with 3HP should be avoided.

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