Skeletal muscle regeneration failure in ischemic-damaged limbs is associated with pro-inflammatory macrophages and premature differentiation of satellite cells.

Kevin W Southerland,Yueyuan Xu,Derek T Peters,Xin Lin,Xiaolin Wei,Yu Xiang,Kaileen Fei,Lindsey A Olivere,Jeremy M Morowitz,James Otto, Qunsheng Dai,Christopher D Kontos,Yarui Diao

Genome medicine（2023）

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摘要

Collectively, our research provides the first single-cell transcriptome atlases of skeletal muscle from CLTI patients and a murine CLTI model, emphasizing the crucial role of macrophages and inflammation in regulating muscle regeneration in CLTI through interactions with MuSCs.

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关键词

skeletal muscle regeneration failure,macrophages,limbs,cells,ischemic-damaged,pro-inflammatory

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