The Influence of Chirality on the -Amino-Acid Naphthalenediimides/G-Quadruplex DNA Interaction

G-quadruplexes (G4s) have been identified as a potential alternative chemotherapy target. A series of eight beta-amino acid derived naphthalenediimides (NDI) were screened against a series of oncogenic G4 sequences: c-KIT1, h-TELO, and TBA. Three sets of enantiomers were investigated to further our understanding of the effect of point chirality on G4 stabilisation. Enantioselective binding behaviour was observed with both c-KIT1 and h-TELO. Docking studies using GNINA and UV-vis titrations were employed to better understand this selective binding behaviour.