An organic free radical generator independent on hydrogen peroxide for chemodynamic and immunotherapy in vivo

It is desirable to develop a free radical generator that is neither dependent on hydrogen peroxide nor external stimuli-triggered to achieve effective tumor treatment. Herein, the free radical generator MNPs-mCPBA was constructed with Zn 0.4 Co 0.6 F e2 O 4 @Zn 0.4 Mn 0.6 Fe 2 O 4 nanoparticles (MNPs) and 3chloroperbenzoic acid (mCPBA). We believe that the iron (II) on the surface of MNPs-mCPBA maybe represent high reactive activity and promote the generation of a large number of organic free radicals (C 6 H 4 ClCOOO & BULL;) in an acidic tumor microenvironment, which realizes the acid-dependent tumor treatment strategy independent on the H 2 O 2 level in tumors. In addition, the generated organic free radicals (C 6 H 4 ClCOOO & BULL;) effectively induced immunogenic cell death (ICD) and increased T cell infiltration. Under the synergetic treatment with an anti-PD-L1 antibody ( & alpha;-PD-L1), a favorable anti-tumor effect was achieved. & COPY; 2023 Published by Elsevier Ltd on behalf of The editorial office of Journal of Materials Science & Technology.