Advancing chemical lability assessments of organic matter using a synthesis of FT-ICR MS data across diverse environments and experiments

•Dissolved organic matter (DOM) lability can be estimated using FT-ICR MS data.•The molecular lability boundary (MLB) approach is updated using new data.•The fraction of MLBL DOM decreases during heterotrophic and thermal degradation.•The fraction of MLBL OM increases during photo-processing of oils.•MLBL laboratory experimental results extend understanding of DOM from field samples.