Electrochemical Three-Component Reaction to Construct N-(a-alkoxyalkyl)benzotriazoles

N-(a-alkoxyalkyl)benzotriazoles are of great importance for biochemical and antitumor activity. A feasible protocol has been developed for the synthesis of N-(a-alkoxyalkyl)benzotriazoles using azoles, aldehydes and alcohols as substrates under electrochemical conditions. The reaction is carried out under acid catalyst- and oxidant-free conditions, so that a variety of synthetically useful nitrogen heterocyclic derivatives can be obtained. More meaningfully, a gram-scale synthetic approach was employed to demonstrate the scale-up applicability of this transformation.