The Mechanism Study of Single Nucleotide Polymorphism rs3094165 Regulating the Progression of Hepatocellular Carcinoma via Modulating NADH Dehydrogenase Ubiquinone Fe-S Protein-1

Hepatocellular carcinoma (HCC) is a major contributor to global cancer-related mortality, underscoring the urgent need to identify effective prognostic markers. Single nucleotide polymorphisms (SNPs) play an increasingly important role in predicting the prognosis of patients with HCC. In this study, a cohort of 637 HCC patients was enrolled, and various online databases were comprehensively surveyed to identify SNPs that potentially impact HCC patient survival. The results of the Cox regression analysis demonstrated a significant association between rs3094165 and poor prognosis among patients with HCC. Further PM analysis was also employed to control potential IP: 203.8.109.20 On: Sun, 17 Sep 2023 05:57:26 biases, and the results remained consistent. These findings suggest tat SNPs can serve as reliable Copyright: American Scientific Publishers prognostic markers for HCC patients. Then,DeliverdwebyconductdIngentafunctional experiments to explore the molecular mechanism and confirmed that rs3094165 potentially regulates the progression of HCC by modulating the expression of the NDUFS1. Taken together, our study provides a comprehensive analysis of SNPs associated with HCC prognosis, and highlights the importance of rs3094165 as potential biomarkers for predicting poor prognosis of HCC patients. Our findings also shed light on the influence of rs3094165 on HCC progression by regulating NDUFS1 expression.