Colloidal Trehalose Nanoparticles: Sacrifice Templates for Hollow Silica Nanospheres

We demonstrate a trehalose nanoparticle (Tre NP) colloid first prepared by an injection method, and applied to a sacrifice template to create a hollow silica nanosphere. The Tre NP is successfully coated with a uniform layer of silica via sol-gel process, and removed simply by soaking in water, leading to the formation of the hollow nanostructure.