Coexistence of DOPG model membranes and β -aescin micelles: a combined scattering and NMR study

Friederike Gräbitz-Bräuer,Carina Dargel,Ramsia Geisler,Pascal Fandrich,Viktor Sabadasch,Lionel Porcar,Andreas Mix,Thomas Hellweg

COLLOID AND POLYMER SCIENCE（2023）

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摘要

The saponin β -aescin is well known for its self-aggregation above the critical micelle concentration ( cmc ) and its interaction with model membranes made of zwitterionic phospholipids including the formation of mixed bicelle systems. In this study, we investigate the interaction of β -aescin with small unilamellar vesicles (SUVs) made of the negatively charged lipid 1,2-dioleoyl- sn -glycero-3-phosphoglycerol (DOPG). The study is conducted at a pH value at which aescin is negatively charged as well, and mixtures up to an aescin content of 50 mol

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关键词

Small angle X-ray scattering (SAXS), Small angle neutron scattering (SANS), Wide angle X-ray scattering (WAXS), Small unilamellar vesicles (SUV), Micelles, 1,2-dioleoyl-sn-glycero-3-phosphoglycerol (DOPG), Aescin, Saponin, Bio-surfactant, GIFT, SasView, Diffusion ordered spectroscopy (DOSY)

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