Strict versus Liberal use of Sentinel Node Biopsy in Breast Cancer Surgery. Any clinical outcome difference? A 20-year experience.
BREAST CARE(2024)
摘要
IntroductionAs applied to early Breast Cancer (BC) patients, Sentinel-node Biopsy (SNB) has undergone major changes over the years, especially concerning the widening of indication criteria or skipping systematic axillary lymph node dissection (ALND) after a positive SN. We aimed to ascertain whether a strict versus a more liberal use of SNB resulted in different clinical outcomes in our clinical experience. MethodsWe studied consecutive BC patients undergoing SNB between January 1, 2000, and March 31, 2020. There were 1,587 patients and 1,634 SNB procedures. Cases were divided into two study groups: the "strict" SNB group (unifocal tumors up to 35 mm in whom ALND was always performed for a positive SN, amounting to 1183 SNBs), and the "liberal" SNB group (extended tumor size up to selected T3 cases, as well as multifocal or bilateral disease, and patients with previous contralateral BC, not always followed by ALND after a positive SN, amounting to 451 SNBs). Patients were closely followed-up to the end of the study.ResultsClinico-pathological variables were strikingly different between study groups, with the liberal group showing a higher risk profile. Cox regression analysis for disease recurrence did not show significant differences in axillary, lymph-node, or locoregional recurrence rates or distant relapse. Neither were differences in survival between groups.ConclusionIt seems reasonable to adopt the liberal SNB approach, as the goal of surgical management in early BC patients must be attaining optimal locoregional disease control, no matter the differences in distant metastatic spread rates across different BC risk profiles
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关键词
Breast Cancer,Sentinel Node Biopsy,Axillary Recurrence,Survival
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