An adhesive hydrogel implant combining chemotherapy and tumor microenvironment remodeling for preventing postoperative recurrence and metastasis of breast cancer

Jianye Li, Qing Chen,Shiyu Li, Xuelian Zeng,Jiaqi Qin,Xin Li, Zhaoxia Chen, Wenxia Zheng,Yanbing Zhao,Ziming Huang,Xiangliang Yang,Lu Gan

CHEMICAL ENGINEERING JOURNAL（2023）

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Abstract

•HDP hydrogels exhibit the favorable adhesion and viscoelastic behaviors.•DOX/Met@HDP shows persistent drug retention and tumor acidic microenvironment-controlled drug release.•DOX/Met@HDP efficiently kills residual tumor cells.•DOX/Met@HDP inhibits adipocyte-promoted proliferation and metastasis of tumor cells.•DOX/Met@HDP efficiently inhibits the recurrence and metastasis of breast cancer.

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Key words

Adhesive hydrogels,Adipocytes,Angiogenesis,Tumor recurrence and metastasis,Breast cancer

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