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Methotrexate and trimethoprim-sulfamethoxazole combination

Samuel Legeay,Sebastien Faure

ACTUALITES PHARMACEUTIQUES（2023）

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Abstract
Methotrexate and trimethoprim-sulfamethoxazole combination. Methotrexate and trimethoprim-sulfamethoxazole are antimetabolites indicated for autoimmune diseases and infections. Their co- administration can lead to serious adverse effects that may be life-threatening. It is strictly contraindicated. An alternative treatment must be proposed. (c) 2023 Elsevier Masson SAS. All rights reserved
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Key words
folic acid metabolism, methotrexate, serious adverse reaction, trimethoprim-sulfamethoxazole
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