A mucin-foraging bacterium modulates breakdown of oral tolerance

Dietary fibre deprivation in mice increases the abundance of gut microbial mucin-degrading species, leads to barrier dysfunction and increases local type 2 inflammation. In a tractable human microbiota mouse model, the presence of Akkermansia muciniphila results in increased anti-commensal IgE and type 2 immune responses, worsening food allergy symptoms following sensitization.