Alkyl radicals from diacyl peroxides: metal-/base-/additive-free photocatalytic alkylation of N-heteroaromatics

Alkyl diacyl peroxides were demonstrated to be efficient alkylating reagents for the visible-light-induced 4CzIPN-catalyzed direct C-H alkylation of N-heteroaromatics. With this metal-/base-/additive-free photocatalytic system, 57 examples of alkylated N-heteroaromatics scaffolds including 1,2,4-triazine-3,5(2H,4H)-diones (i.e. azauracils), quinoxalin-2(1H)-ones, 2H-benzo[b][1,4]oxazin-2-ones and quinoxalines were successfully synthesized.