Relationship Between rs1800896 and rs1465618 Polymorphisms in Prostate Adenocarcinoma in the Iranian Population

Golnoosh Tolue , Seyed Abdolhamid Angaji * , Behnaz Beikzadeh , Hengameh Alibeik , Raheleh Roudi , Behzad Narouie Background and Objective: Prostate cancer is a malignancy affecting men. Identifying risk factors for prostate cancer is crucial for the potential development of interventions and expanding our biological understanding of this disease. The present study investigated the association of rs1800896 and rs1800896 with prostate adenocarcinoma. Methods: This case-control study was conducted on 176 men, including 78 patients with prostate adenocarcinoma (case group) and 98 men with benign prostatic hyperplasia (control group), who visited the Labafinejad Educational and Treatment Center in Tehran, Iran. Genotyping was performed using the Tetra ARMS-PCR (amplification refractory mutation system-polymerase chain reaction) method. Results: There was no statistically significant difference between the case and control groups in the genotype frequency of rs1800896 and rs1465618. However, the rs1800896 polymorphism was associated with PSA levels less than or equal to 4 ng/mL (P<0.05). Significant associations were found between rs1800896 and rs1465618 polymorphisms and clinical features, such as perineural invasion (P<0.05). Conclusion: The rs1800896 and rs1465618 polymorphisms were not associated with the risk of prostate adenocarcinoma.