Expanding Indications for Surgical Resection in Hepatocellular Carcinoma What is the Evidence?

Hepatocellular carcinoma (HCC) is the third leading cause of cancer-related deaths worldwide and the fastest-rising cause of cancer related mortality in the United States.1,2 Factors determining outcome following HCC diagnosis are complex and heterogenous in nature, dependent not only on tumor burden and biology, but on underlying liver function and patient performance status. These complexities require maintaining a tenuous balance between tumor- and patient-related factors with decisions regarding treatment strategies best made in the context of a multidisciplinary Surgical resection is the one of the mainstay curative treatment options in patients with localized, early-stage HCC associated with 5 year overall survival rates