Hybrid PET/MRI Analysis in the Juvenile Huntington Disease Evaluation

Hybrid PET/MRI is an emerging approach to simultaneously investigate the connection of intrinsic metabolic with functional brain changes. In this work, we propose an image analysis workflow for longitudinal PET/MRI study in Juvenile-onset Huntington's Disease(JoHD) aiming to evaluate progressive disease-related volumetric, functional, and metabolic alterations. This examination/methodology could be very useful in the characterization of the rapidly worsening course of this degenerative pathology. Also, our main contribution lays in the multimodal hybrid PET/MRI data-fusion approach to identify features as potential markers of JoHD progression, and to support future trials in test drugs and treatments.