Genome-driven discovery of new serrawettin W2 analogues from Serratia fonticola DSM 4576

Haolin Qiu, Yang Xiao,Ling Shen,Tao Han, Qiang He,Aiying Li,Peng Zhang,Xiaofeng Cai

Organic & biomolecular chemistry（2023）

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Abstract

By expressing a multimodular NRPS gene sefA from Serratia fonticola DSM 4576 in E. coli, four new serrawettin W2 analogues, namely sefopeptides A-D (1-4), were isolated and structurally characterized and their biosynthesis was proposed. A bioactivity assay showed that sefopeptide C (3) exhibits moderate cytotoxic activity against acute promyelocytic leukemia NB4 cells.

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