TAZ stimulates exercise-induced muscle satellite cell activation via Pard3-p38 MAPK-TAZ signalling axis.

Kyung Min Kim,Gi Don Yoo,Woong Heo,Ho Taek Oh,Jeekeon Park,Somin Shin,Youjin Do,Mi Gyeong Jeong,Eun Sook Hwang,Jeong-Ho Hong

Journal of cachexia, sarcopenia and muscle（2023）

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摘要

Our results demonstrate a novel mechanism of TAZ-induced satellite cell activation after muscle injury and exercise, suggesting that activation of TAZ in satellite cells may ameliorate the muscle ageing phenotype and may be an important target protein for the drug development in sarcopenia.

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