The impact of liver fibrosis on the progression of hepatocellular carcinoma via a hypoxia-immune-integrated prognostic model

•A Fibrosis-Hypoxia-Glycolysis-Immune Prognostic Model (FHGISig) could significantly predict disease progression in HCC.•We revealed a close correlation between FHGISig and immune cell infiltration level as well as immune checkpoints.•TFF3 mRNA was significantly lower in cirrhotic HCC patients compared with non-cirrhotic ones.•Liver fibrosis is a poor-prognostic factor for HCC.